BIO 331- CELL BIOLOGY

COURSE SYLLABUS: FALL 2003

Instructor: Dr. Suzanne Byrd

Cammack 221, phone # 622-1712

Suzanne.Byrd@eku.edu

Text: Cell and Molecular Biology, Gerald Karp, 3^rd edition

Primary Course Objectives:

1. To familiarize the student with the basic structure and function of cellular organelles.

2. To integrate modern molecular biology with traditional cell structure and function.

3. To provide, where possible, the implications of cell and molecular biology in human health.

4. To introduce the student to modern techniques and approaches to research questions in cellular and molecular biology.

Class Attendance Policy: Regular class attendance is required of all students. Credit for the course will not be allowed when 6 absences (20% of class meetings) has occurred.

Course Evaluation:

There will be 3 lecture exams worth 100 points each and a semi-cumulative final exam worth 150 points. Each student will write a research paper covering a topic in cell biology (All topics must be approved by the instructor). An outline of the research paper with at least 2 journal references must be turned in one month before the paper deadline. In addition, over the course of the semester, questions about the reading and lecture material will be given as homework assignments and/or quizzes.

Exam I 100 Grading scale:

Exam II 100 90-100% A

Exam III 100 80- 89% B

Final Exam 150 70- 79% C

Homework/Quizzes/Outline 100 60- 69% D

Research paper 100 <60% F

TOTAL POINTS 650

Dropping the course: The last day to withdraw from this course without receiving a grade is Tuesday, October 14, 2003.

If you are registered with the Office of Services for Individuals with Disabilities, please make an appointment with the course instructor to discuss any academic accommodations you need. If you need academic accommodations and are not registered with the Office of Services for Individuals with Disabilities, please contact the Office directly either in person on the first floor of the Turley House or by telephone at (859) 622-1500 V/TTY. Upon individual request, this syllabus can be made available in alternative forms.

English Composition: All work done in this course which requires writing will be graded not only on the basis of content and accuracy, but also will be subject to grading on organization, conciseness, spelling, and other components of good English composition. This applies to all written examination answers and all other written work.

Plagiarism: As stated in the University Handbook for Students, "cheating, plagiarism, or other forms of academic dishonesty including the acquisition, without permission, of test or other academic material belonging to a member of the University faculty or staff" will not be tolerated. Disciplinary action will be taken if evidence of academic dishonesty occurs.

FALL 2003 COURSE OUTLINE

Date Topic

Aug. 21 R Introduction. Overview of cell structure. Prokaryotic vs. Eukaryotic cells (Chap.1)

26 T Membrane composition, Passive and Active transport (Chap. 4)

28 R Passive and Active transport, Membrane potentials and nerve conduction (Chap. 4)

Sept. 2 T Cell recognition, Surface receptors (Chap. 7)

4 R Surface receptors and receptor-response mechanisms (Chap. 7,15)

9 T Cell adhesions and cell junctions (Chap. 15)

11 R Metabolism (Chap. 3) and Chaperones (Chap. 2)

16 T Review

18 R EXAMINATION I (100 points)

23 T Mitochondrial structure, electron transport system, Mt protein transport (Chap. 5)

25 R Chloroplast structure and photosynthesis (Chap. 6)

30 T Mitochondrial and chloroplast genomes (Chap. 6), Overview of cytoskeleton (Chap. 9)

Oct. 2 R Cytoskeleton, Cell motility and microtubules (Chap. 9)

*Research paper outline due*

7 T Microfilament structure and cellular motility (Chap. 9)

9 R Structure of intermediate filaments and cytoskeleton (Chap. 9)

14 T Cytoskeleton dynamics (Chap. 9), Review

16 R EXAMINATION II (100 points)

21 T Structure of the nuclear envelope (Chap. 12)

23 R Transport through the nuclear envelope (Chap. 12)

28 T Eukaryotic chromosome structure (Chap. 10)

30 R Control of gene expression (Chap. 12)

Nov. 4 T Transcription and Translation (Chap. 11)

*Research paper due*

6 R ****** NO CLASS ******

11 T Regulation of transcription (Chap 11)

13 R Protein synthesis and transport (Chap. 8)

18 T Exocytosis and Endocytosis (Chap. 8)

20 R EXAMINATION III (100 points)

25 T Cell Cycle (Chap. 14)

27 R *****THANKSGIVING , NO CLASS *****

Dec. 2 T Factors controlling the cell cycle (Chap. 14)

4 R Biology of Cancer (Chap. 16)

9 T Cancer: Characteristics and Causes (Chap. 16), Review

FINAL EXAMINATION: Thursday, Dec. 11, 8:00-10:00 am

BIO 331- CELL BIOLOGY

COURSE SYLLABUS: FALL 1999

Instructor: Dr. Suzanne Byrd

Cammack 221, phone #1712

Text: Cell and Molecular Biology, Gerald Karp, 2^ND edition

Primary Course Objectives:

1. To familiarize the student with the basic structure and function of cellular organelles.

2. To integrate modern molecular biology with traditional cell structure and function.

3. To provide, where possible, the implications of cell and molecular biology in human health.

4. To introduce the student to modern techniques and approaches to research questions in cellular and molecular biology.

Course Evaluation:

There will be 4 lecture exams worth 100 points each and a semi-cumulative final exam worth 150 points. Over the course of the semester, questions about the reading and lecture material will be given as homework assignments worth a total of 50 points. Each student will critically review two primary research papers in the field of cell biology. These type-written reviews will be worth 50 points each.

Exam I 100 Grading Scale:

Exam II 100 A = 90% and above

Exam III 100 B = 80-89%

Exam IV 100 C = 70-79%

Final Exam 150 D = 60-69%

Homework 50 F = 59% and below

Literature reviews 100

TOTAL POINTS 700

Class Attendance Policy: Regular class attendance is required of all students. Credit for the course will not be allowed when 7 absences (20% of class meetings) has occurred.

Midterm grade: Midterm grades may be calculated by totaling the first 2 lecture exams, the homework, and the first literature review and dividing by the total points possible.

Dropping the course: The last day to withdraw from this course without receiving a grade is October 15, 1999

COURSE OUTLINE

Date Topic

Aug. 24 T Introduction. Overview of cell structure. Prokaryotic vs. Eukaryotic cells (Chap.1)

26 R Membrane composition (Chap. 4)

27 F Passive and Active transport (Chap. 4)

31 T Membrane potentials and nerve conduction (Chap. 4)

Sept. 2 R Cell recognition (Chap. 7)

7 T Surface receptors and receptor-response mechanisms (Chap. 7,15)

9 R Cell adhesions and cell junctions (Chap. 15)

14 T EXAMINATION I (100 points)

16 R Metabolism (Chap. 3) and Chaperones (Chap. 2)

17 F Mitochondrial structure and electron transport system (Chap. 5)

21 T Mitochondrial protein transport (Chap. 5)

23 R Chloroplast structure and photosynthesis (Chap. 6)

28 T Photosynthesis, mitochondrial and chloroplast genomes (Chap. 6)

*First Literature review due*

30 R Overview of cytoskeleton (Chap. 9)

Oct. 1 F Cell motility and microtubules (Chap. 9)

5 T EXAMINATION II (100 points)

7 R Microfilament structure and cellular motility (Chap. 9)

12 T Structure of intermediate filaments and cytoskeleton (Chap. 9)

14 R Major domains of the cytoskeleton (Chap. 9)

19 T Cytoskeleton dynamics (Chap. 9)

21 R Eukaryotic chromosome structure (Chap. 10)

22 F Eukaryotic chromosome structure, cont'd. (Chap. 10)

26 T Structure of the nuclear envelope (Chap. 12)

28 R Transport through the nuclear envelope (Chap. 12)

Nov. 2 T EXAMINATION III (100 points)

4 R Control of gene expression (Chap. 12)

5 F Regulation of transcription (Chap 11)

9 T Transcription continued (Chap. 11)

*Second Literature Review due*

11 R Transcription and Translation (Chap. 11)

16 T Protein synthesis (Chap. 8)

18 R Protein transport (Chap. 8)

19 F Exocytosis and Endocytosis (Chap. 8)

23 T EXAMINATION IV (100 points)

30 T Cell Cycle (Chap. 14)

Dec. 2 R Factors controlling the cell cycle (Chap. 14)

7 T Biology of Cancer (Chap. 16)

9 R Cancer: characteristics and causes (Chap. 16)

10 F Cancer: characteristics and causes, cont'd. (Chap. 16)

FINAL EXAMINATION: Tuesday, Dec. 14, 10:30-12:30