BIO 378
Lecture 11: Digestion



 

A. The Digestive or Gastrointestinal tract
    1. Three main functions

        a. Ingestion-receiving food
 

        b. Digestion-breakdown of food particles into particles small enough to pass through cell membranes
 

        c. Transfer of food into circulation

    2. Functional units
        a. Oral Cavity
            1). Teeth

                a). incisors and canines: cutting and tearing

                b). premolars and molars: mastication

            2). Tongue--pushes food around for mastication
 

             3). Salivary glands

                    - Saliva: consists largely of water and protein and lubricates the food for
                            easier swallowing.  Saliva contains the enzyme salivary amylase.
                            This enzyme begins the digestive process by breaking down carbohydrates into simpler sugars         b. Pharynx and Esophagus
            1). pharynx: throat, shared by digestive and respiratory systems

            2). esophagus: transports food to the stomach

        c. Stomach

            1). The walls of the stomach contain three (3) layers of smooth muscle.  The innermost
                    lining of the stomach is an epithelial layer and produces mucous

                a). helps to lubricate the stomach wall and facilitate food movement
 

                b). helps to protect the wall of the stomach from the acid produced by other cells
 
 

            2). The exocrine glands of the stomach contain two (2) types of secreting cells
                a). chief:  secrete pepsinogen (a protein) which is quickly converted into an
                        enzyme, pepsin, by the acid of the stomach.  Pepsin is an
                        enzyme that breaks down proteins.  Proteins are the only nutrients
                        degraded in the stomach.

                b). parietal: secrete HCl  .  The primary function of the acid is to
                        convert pepsinogen to pepsin.  Acid, also, helps break down the food
                        in the stomach into very small particles.

        d. Small Intestine: where most of the enzymatic activity and absorption occurs.
            1). Duodenum
                a). Pancreatic enzymes and bile from the liver enter the small
                        intestine, initiating digestion.

                b). villi: microscopic hair-like projections--increase amount of surface area for absorption

                c). cells that line the small intestine produce enzymes of several types, and actively
                        transport sugars and amino acids across membranes.

                d). the small intestine enzmyes work with enzymes from the pancreas to break
                        down carbohydrates, proteins, fats
                        into sugars, amino acids, & fatty acids

                e). these smaller molecules pass through the epithelial wall of the small intestine
                        into the bloodstream

            2). Jejunum - 2nd portion of small intestine and helps digest proteins and fats

            3). Ileum - last portion of the small intestine

        e. Accessory organs associated with the Duodenum

          1). Liver: produces bile that is stored in the gall bladder
                    a). also:     *supplies quick energy
                                     * metabolizes alcohol
                                     *makes proteins
                                     * stores vitamins and minerals
                                     * regulates blood clotting
                                     *regulates cholesterol production
                                     *detoxifies poisons

                    b). components of bile combine to render fat soluble
                                emulsification: breakdown of large fat droplets into
                                    very small droplets that can be digested more efficiently by enzymes.

        2). Pancreas: large gland situated near the junction of the stomach and the small intestine.
                The pancreas has two (2) types of exocrine cells.
                     a). secretes digestive enzymes - produces enzymes that act in the duodenum
                             break down carbohydrates, proteins, and fats.

                     b). secretes a base, bicarbonate ion.  This base neutralizes the acid
                              solution (chyme) from the stomach, permitting digestive enzymes to
                              function.  Without this neutralizatoin, the acid would destroy
                              the pancreatic enzymes.  Secretion of bicarbonate is controlled by
                              secretin (a hormone).

        f. Large Intestine: serves to compact the solids  remaining after digestion.

          1). water and a few ions (e.g. sodium) are absorbed through the walls of the large intestine.

            2). undigested material then passes into the rectum and is finally eliminated through
                the anus.

B. Digestion and Absorption in the stomach
    1. HCl  + churning action (mechanical or physical breakdown of food) results in food broken down into small particles.

    2. breakdown results in numerous small particles that have much more exposed surface area than would few, large particles.  This allows the enzymes to more efficiently attack and breakdown food.

    3. chyme: mixture of small food particles + acid + mucous
 

    4. Little absorption occurs through the walls of the stomach. Only very small molecules such
            as water can pass through the walls and into the blood.


Useful links:

Hepatitis

Jaundice

Stomach Ulcers

Gastrointestinal Disease


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